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Despite delivering gene-specific silencing, the use of deoxyribozymes (DNAzymes) for cancer therapy is limited by toxicity due to off-target effects. Here, the authors develop a multi-component DNAzyme, targeting both miRNA-21 and HSP70, to induce tumour-specific sensitisation to photothermal therapy in preclinical models of pancreatic cancer.

尽管脱氧核酶（deoxyribozymes，DNAzymes）可实现基因特异性沉默，但其用于癌症治疗时会因脱靶效应产生毒性，从而限制了其应用。本研究中，研究者开发了一种多组分脱氧核酶，可同时靶向微小RNA-21（miRNA-21）与热休克蛋白70（HSP70），并在胰腺癌临床前模型中诱导肿瘤特异性的光热疗法增敏效应。