Multiorgan effects of IUGR caused by maternal protein depletion in rats (Placenta, Kidney, Heart, Lung, Liver). Rattus norvegicus

All genome expression changes investigated on pools of growth restricted rats (at term) compared to control rats. The protocol of growth restriction (length, duration) has been extensively described in Buffat et al (Journal of Pathology 2007a and Endocrinology, 2007b) Overall design: Ten hybridizations, two technical replicates, were carried out using RNAs prepared from pooled organs from 4 to 6 pups.

本数据集分析足月生长受限大鼠（growth restricted rats）混合样本与对照组大鼠的全基因组表达变化。该生长受限实验方案（含干预时长与周期）已在Buffat等人2007年发表于《Journal of Pathology》的研究（2007a）及2007年发表于《Endocrinology》的研究（2007b）中得到详尽阐述。实验整体设计：本研究使用4至6只幼崽的混合器官提取的RNA，完成10次杂交实验，包含2次技术重复（technical replicates）。