The EZH2-PRC2-H3K27me3 axis governing the endometrial cell cycle and differentiation for successful blastocyst invasion

Ezh2-catalyzing H3K27 trimethylation regulates uterine epithelial and stromal differentiation and blastocyst invasion, contributing to successful pregnancy outcomes. ChIP-seq analysis using uteri from Ezh2-floxed control mice and uterine-specific KO mice of Ezh2 (Ezh2 uKO); RNA-seq analysis using uteri from Ezh2-floxed control mice and uterine-specific KO mice of Ezh2; RNA-seq analysis using endometrial tissues from human patients with or without recurrent implantation failure (RIF)

Ezh2催化的H3K27三甲基化可调控子宫上皮与基质分化及囊胚侵袭过程，对成功妊娠结局具有积极贡献。本数据集包含三类组学实验分析：分别使用Ezh2-floxed对照小鼠与子宫组织特异性敲除Ezh2的小鼠（Ezh2 uKO）的子宫组织进行染色质免疫共沉淀测序（ChIP-seq）分析；分别使用上述Ezh2-floxed对照小鼠与Ezh2 uKO小鼠的子宫组织进行RNA测序（RNA-seq）分析；分别选取伴或不伴复发性植入失败（Recurrent Implantation Failure, RIF）的人类患者的子宫内膜组织进行RNA-seq分析。