Additional file 3 of Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

Additional file 3:Table S1. Strength of the genetic instrument in predicting age at menarche in UK Biobank. Table S2. Findings from the main analysis of the genetic risk score for age at menarche. Table S3. Finding from the main analysis of the genetic risk score for age at menarche after additional adjustment for chip used for the genotyping. Table S4. Finding from the main analysis of the genetic risk score for age at menarche after Steiger filtering. Table S5. Findings from the sensitivity analysis of the genetic risk score for age at menarche excluding SNPs associated with childhood body-mass index. Table S6. Findings from the sensitivity analysis of the genetic risk score for age at menarche excluding SNPs associated with childhood and/or adult body-mass index. Table S7. MR-Egger intercept. Table S8. Results from MR-PRESSO global test for pleoitropy and distortion tests. Table S9. Strength of the genetic instrument in predicting age at menarche in ALSPAC. Table S10. Strength of the genetic instrument in predicting body-mass index and height in UK Biobank. Table S11. Findings from the multivariable mendelian randomization analysis further adjusting for body-mass index and height. Table S12. Post hoc power calculation analyses for the replication analyses.

附加文件3：表S1。英国生物银行（UK Biobank）中用于预测月经初潮年龄的遗传工具变量强度。表S2。月经初潮年龄遗传风险评分主分析结果。表S3。在针对基因分型所用芯片进行额外校正后，月经初潮年龄遗传风险评分主分析结果。表S4。经Steiger过滤后，月经初潮年龄遗传风险评分主分析结果。表S5。排除与儿童体质量指数相关的单核苷酸多态性（Single Nucleotide Polymorphism, SNPs）后，月经初潮年龄遗传风险评分敏感性分析结果。表S6。排除与儿童及/或成年体质量指数相关的单核苷酸多态性（SNPs）后，月经初潮年龄遗传风险评分敏感性分析结果。表S7。MR-Egger截距。表S8。MR-PRESSO全局多效性检验及偏倚检验结果。表S9。ALSPAC中用于预测月经初潮年龄的遗传工具变量强度。表S10。英国生物银行中用于预测体质量指数与身高的遗传工具变量强度。表S11。在校正体质量指数及身高后开展的多变量孟德尔随机化（Mendelian randomization, MR）分析结果。表S12。重复分析的事后效力计算分析结果。