BindingDB Entry 50018682: 4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry.

Small molecule binding data for protein Cytoplasmic tyrosine-protein kinase BMX, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Insulin-like growth factor 1 receptor, Nuclear receptor subfamily 4 group A member 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret, Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-3, Receptor tyrosine-protein kinase erbB-4, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Fgr, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Yes, and Vascular endothelial growth factor receptor 2, Uniprot O00329, P00519, P00533, P04626, P06239, P06241, P07947, P07948, P07949, P08069, P09769, P11362, P12931, P21802, P21860, P22455, P22607, P35968, P42336, P42338, P48736, P51813, P52333, Q06187, Q15303, and Q92570

本数据集收录了胞质酪氨酸蛋白激酶BMX (Cytoplasmic tyrosine-protein kinase BMX)、表皮生长因子受体 (Epidermal growth factor receptor)、成纤维细胞生长因子受体1 (Fibroblast growth factor receptor 1)、成纤维细胞生长因子受体2 (Fibroblast growth factor receptor 2)、成纤维细胞生长因子受体3 (Fibroblast growth factor receptor 3)、成纤维细胞生长因子受体4 (Fibroblast growth factor receptor 4)、胰岛素样生长因子1受体 (Insulin-like growth factor 1 receptor)、核受体亚家族4A组成员3 (Nuclear receptor subfamily 4 group A member 3)、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基α亚型 (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform)、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基β亚型 (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform)、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基δ亚型 (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform)、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基γ亚型 (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform)、原癌基因酪氨酸蛋白激酶Src (Proto-oncogene tyrosine-protein kinase Src)、原癌基因酪氨酸蛋白激酶受体Ret (Proto-oncogene tyrosine-protein kinase receptor Ret)、受体酪氨酸蛋白激酶erbB-2 (Receptor tyrosine-protein kinase erbB-2)、受体酪氨酸蛋白激酶erbB-3 (Receptor tyrosine-protein kinase erbB-3)、受体酪氨酸蛋白激酶erbB-4 (Receptor tyrosine-protein kinase erbB-4)、酪氨酸蛋白激酶ABL1 (Tyrosine-protein kinase ABL1)、酪氨酸蛋白激酶BTK (Tyrosine-protein kinase BTK)、酪氨酸蛋白激酶Fgr (Tyrosine-protein kinase Fgr)、酪氨酸蛋白激酶Fyn (Tyrosine-protein kinase Fyn)、酪氨酸蛋白激酶JAK3 (Tyrosine-protein kinase JAK3)、酪氨酸蛋白激酶Lck (Tyrosine-protein kinase Lck)、酪氨酸蛋白激酶Lyn (Tyrosine-protein kinase Lyn)、酪氨酸蛋白激酶Yes (Tyrosine-protein kinase Yes)以及血管内皮生长因子受体2 (Vascular endothelial growth factor receptor 2)共26种蛋白质的小分子结合数据；对应UniProt编号分别为O00329、P00519、P00533、P04626、P06239、P06241、P07947、P07948、P07949、P08069、P09769、P11362、P12931、P21802、P21860、P22455、P22607、P35968、P42336、P42338、P48736、P51813、P52333、Q06187、Q15303及Q92570。