The_Surveillance_for_Enteric_fever_in_Asia_Project__SEAP_. The_Surveillance_for_Enteric_fever_in_Asia_Project__SEAP_

The Surveillance for Enteric fever in Asia Project (SEAP) is a prospective study aimed at characterizing the burden of enteric fever in Bangladesh, Nepal and Pakistan through hospital and enhanced laboratory-based surveillance, longterm case follow-up, and health care utilization surveys. The overall study objectives include describing the clinical manifestations, severity of illness, long-term sequelae of illness, risk factors for disease, cost of illness, and antimicrobial resistance patterns of enteric fever isolates. Whole-genome sequencing of 3,000 enteric fever isolates collected through the SEAP surveillance system will generate critical information to gain insight into epidemiologic transmission patterns, further characterize the current and the evolving patterns of antimicrobial resistance, and add to the understanding of the relationship between genetics and disease severity. These sequences will also serve as the baseline in evaluations of future mass typhoid vaccination campaigns to assess if the vaccine has an impact on circulating strains. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/亚洲肠热监测项目（Surveillance for Enteric fever in Asia Project, SEAP）是一项前瞻性研究，旨在通过医院监测、强化实验室监测、长期病例随访以及医疗服务利用调查，明确孟加拉国、尼泊尔与巴基斯坦的肠热疾病负担。本研究的总体目标包括描述肠热分离株的临床表现、疾病严重程度、长期后遗症、疾病危险因素、疾病经济负担以及抗菌药物耐药谱。通过SEAP监测系统收集的3000株肠热分离株的全基因组测序工作，将生成关键信息，以深入解析流行病学传播模式，进一步阐明当前及不断演变的抗菌药物耐药格局，并增进对病原菌遗传学与疾病严重程度之间关联的认知。上述测序数据还将作为基线数据，用于未来大规模伤寒疫苗接种行动的效果评估，以判断疫苗是否对循环菌株产生影响。本数据集属于预发布数据。若需了解威康桑格研究所（Wellcome Trust Sanger Institute）共享的预发布数据的规范使用要求，包括任何出版暂缓条款的相关细节，请访问http://www.sanger.ac.uk/datasharing/