Associations between toxicity and individual level factors.

Note: Age was centered; and missing values for BMI, clinical stage, and CD4 cell counts were included as a separate category. Adjusted incidence rate ratios [aIRR] of all-cause toxicity for the interaction between duration of exposure and stavudine dosage were 1.28 (95% CI 1.10–1.49), 0.66 (95% CI 0.49–0.89), and 0.69 (95% CI 0.32–1.51) for the second, third, and fourth years of exposure to stavudine 40 mg, respectively, compared to the first year of stavudine 30 mg. The corresponding aIRR of specific toxicity were 1.14 (95% CI 0.97–1.34), 0.56 (95% CI 0.40–0.79), and 0.47 (95% CI 0.17–1.29), respectively. P value from likelihood rate ratio tests for association were calculated across all categories of a given variable.

注：年龄已进行中心化处理；将身体质量指数（Body Mass Index, BMI）、临床分期及CD4细胞计数的缺失值作为单独类别纳入分析。针对司他夫定40mg暴露的第2、3、4年，其暴露时长与司他夫定剂量的交互作用对应的全因毒性校正发病率比（adjusted incidence rate ratio，aIRR）分别为1.28（95%置信区间[CI] 1.10~1.49）、0.66（95%CI 0.49~0.89）及0.69（95%CI 0.32~1.51），对照基准为司他夫定30mg暴露的第1年。对应的特异性毒性校正发病率比分别为1.14（95%CI 0.97~1.34）、0.56（95%CI 0.40~0.79）及0.47（95%CI 0.17~1.29）。针对指定变量的所有类别，已通过似然比检验计算关联的P值。