Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures. Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures

This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls. Overall design: Use of a rat (Rattus norvegicus) model of hyperthermia-induced seizure to characterize the genomic mechanism underlying febrile seizures in epilepsy. The aim of the study is to identify the genomic differences in hippocampal ventral CA3 region - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with (HS) or without (HNS) seizure after insult and non-insulted controls (CT). Here, samples from the animal of all groups in the P120 time-interval.

本研究旨在通过差异基因表达、微小RNA（miRNAs）以及加权基因共表达网络分析（WGCNA）转录模块，识别致伤后伴或不伴癫痫发作动物与非致伤对照动物之间的基因组差异。总体设计：采用大鼠（Rattus norvegicus）热诱导惊厥模型，解析癫痫中热性惊厥的潜在基因组机制。本研究的具体目标为通过差异基因表达、miRNAs及WGCNA转录模块，鉴定致伤后伴癫痫发作（HS）、不伴癫痫发作（HNS）的动物与非致伤对照（CT）在海马腹侧CA3区的基因组差异。所有组别动物的样本均采集于P120时间区间内。