Lymphoma in leukemic phase in feline coinfected with feline immunodeficiency virus and feline leukemia virus: case report

ABSTRACT The present study aimed to report a case of lymphoma in leukemic phase in feline coinfected with feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). Blood counts, reticulocyte counts, bone marrow avaluation, biochemistry, immunochromatography assay for FIV and FeLV, indirect immunofluorescence (IFA) for FeLV, thoracic radiography and renal citology were performed. This last examination revealed extranodal lymphoma. The association of the clinical signs with the infiltration of a high number of lymphoblastic cells in the bone marrow with cytomorphological criteria of malignancy, atypical mitoses, lymphoglandular corpuscles and hematopoietic material were determinant for the diagnostic conclusion. Lymphoma is a relatively common neoplasm in felines, however the leukemic phase is rare and may represent a clinical diagnostic challenge, making it essential to include bone marrow cytology in the clinical practice of this species.

摘要
本研究旨在报告1例同时感染猫免疫缺陷病毒（FIV）与猫白血病病毒（FeLV）的猫发生白血病期淋巴瘤的病例。本次研究开展了血常规检测、网织红细胞计数、骨髓评估、生化检测、针对FIV与FeLV的免疫层析试验、针对FeLV的间接免疫荧光试验（IFA）、胸部X线摄影及肾脏细胞学检查。其中最后一项检查结果显示为结外淋巴瘤。结合临床症状，骨髓中浸润大量符合恶性细胞形态学标准的淋巴母细胞、存在非典型核分裂象、淋巴腺小体及造血物质，上述特征共同构成了确诊的决定性依据。淋巴瘤是猫类较为常见的肿瘤性疾病，但白血病期淋巴瘤较为罕见，且可能成为临床诊断难题，因此在猫类的临床诊疗实践中，骨髓细胞学检查具有不可或缺的重要性。