TOX Transcriptionally and Epigenetically Programs CD8 T cell Exhaustion [WT vs TOX-KO ATAC-Seq]

Transcriptional and epigenetic features were detected in WT versus TOX-/- P14 T cells following 8 days of Cl-13 infection and in in vitro differentiated CD8 T cells or NIH3T3 fibroblasts following retroviral transduction with control or TOX Overall design: Epigenetic features of WT and TOX-/- P14 T cells following adoptive co-transfer into hosts and subsequent infection with LCMV Cl-13 for 8 days

本数据集检测了两类样本的转录组与表观基因组特征：其一为感染淋巴细胞脉络丛脑膜炎病毒（Lymphocytic Choriomeningitis Virus, LCMV）Cl-13株8天后的野生型（Wild Type, WT）与TOX基因敲除（TOX-/-）P14 T细胞；其二为经对照或TOX逆转录病毒转导的体外分化CD8阳性T细胞，以及NIH3T3成纤维细胞。实验设计概述：将野生型与TOX基因敲除P14 T细胞联合过继转移至宿主后，令其后续感染LCMV Cl-13株8天，以此分析其表观基因组特征。