Gene variants in B6 mice caused by integration of the IAPLTR1a_Mm sequence.

BLAT search with 338 bp of the IAPLTR1a_Mm sequence identified 202 integrations into the B6 genome (90 retrotransposons flanked with LTR sequences and 22 isolated LTR sequences). Thirty-three of the integrations were located in introns of genes. In 8 transcripts modifications caused by the LTR motive were identified; 6 led to a truncated mRNA, and 2 generated an alternative transcription start. Variants in the Adamts13 mRNA caused by the IAPLTR1a_Mm sequence were previously described [27].

BLAT搜索（BLAT）针对IAPLTR1a_Mm序列的338碱基对（base pair, bp）区段进行检索，共在B6基因组（B6 genome）中鉴定出202个整合位点：其中90个为侧翼带有长末端重复序列（long terminal repeat, LTR）的逆转录转座子（retrotransposon），剩余22个为独立长末端重复序列。其中33个整合位点位于基因的内含子区域。在8个转录本中检测到由LTR基序引发的序列修饰；其中6个导致信使RNA（messenger RNA, mRNA）截短，另外2个则产生了可变转录起始位点。此前已有文献报道由IAPLTR1a_Mm序列介导的Adamts13信使RNA（Adamts13 mRNA）变异[27]。