Transcriptional response by murine microglia in Alzheimer's disease

Murine N9 microglial cells were treated with LPS (1µg/ml) for 6 hours. Comparing LPS treated vs. untreated microglial cells will expand upon our previous study comparing the microgial transcriptional reponse from wild-type vs. 5XFAD mice in an effort to further understand the transcriptional response in Alzheimer's disease progression RNA profiles comparing untreated vs. LPS treated microglia

将小鼠源N9小胶质细胞（microglial cells）以脂多糖（LPS，1µg/ml）处理6小时。本研究通过对比经LPS处理与未处理的小胶质细胞，旨在拓展此前针对野生型与5XFAD小鼠的小胶质细胞转录应答相关研究，以进一步解析阿尔茨海默病（Alzheimer's disease）进程中的转录应答机制。本次数据集的RNA表达谱将对比未处理与经LPS处理的小胶质细胞。