Additional file 1 of Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial

Additional file 1: Table S1. Cell lines and mice models established. A total of 96 patients enrolled onto the NMTRC009 MGT trial had at least one tumor cell line generated in the laboratory setting. Since many subjects underwent multiple tumor biopsies and/or bone marrow biopsies, subjects may have >1 unique cell line, either from the same tumor obtained from different biopsy dates or from a different disease site (bone marrow). 47 subjects’ tumors underwent successful implantation into a NOD-SCID mouse to generate at least one PDX model. A total of 56 unique PDX models were generated.附加文件1：表S1 已建立的细胞系与小鼠模型。参与NMTRC009 MGT临床试验的96例受试者中，每例均至少在实验室环境下建立了1株肿瘤细胞系。由于多数受试者接受了多次肿瘤活检和/或骨髓活检，因此同一受试者可拥有多株独特的细胞系，这些细胞系可来源于不同活检时间点获取的同一肿瘤组织，亦或来源于不同病变部位（如骨髓）的样本。其中47例受试者的肿瘤组织成功移植至NOD-SCID小鼠体内，建立了至少1株患者来源的异种移植模型（PDX, Patient-Derived Xenograft）。最终共获得56株独特的PDX模型。