Risk Factors for Major Adverse Events after Surgical Closure of Ventricular Septal Defect in Patients Less than 1 Year of Age: A Single-Center Retrospective

Abstract Objective: To reveal the risk factors that can lead to a complicated course and an increased morbidity in patients 24 hours, intensive care unit (ICU) stay longer than three days, and hospital stay longer than seven days were defined as “prolonged”. Unplanned reoperation, complete heart block requiring a permanent pacemaker implantation, sudden circulatory arrest, and death were considered as significant major adverse events (MAE). Results: VSD closure was performed in 185 patients. The median age was five (1-12) months. There was prolonged MV time in 54 (29.2%) patients. Four patients (2.2%) required permanent pacemaker implantation. Hemodynamically significant residual VSD was observed in six (3.2%) patients. Extracorporeal membrane oxygenation-cardiopulmonary resuscitation was performed in one (0.5%) patient. Small age (

摘要 目的：明确可导致患者病程复杂化且发病率升高的相关危险因素。将重症监护病房（Intensive Care Unit, ICU）停留时长超过3天、住院时长超过7天定义为‘延长’。将非计划再次手术、需植入永久性心脏起搏器的完全性房室传导阻滞、循环骤停及死亡列为重大不良事件（Major Adverse Events, MAE）。结果：本研究共纳入185例接受室间隔缺损（Ventricular Septal Defect, VSD）修补术的患者。患者中位年龄为5（1~12）月龄。其中54例（29.2%）患者机械通气（Mechanical Ventilation, MV）时间延长。4例（2.2%）患者需植入永久性心脏起搏器。6例（3.2%）患者存在血流动力学意义显著的残余室间隔缺损。1例（0.5%）患者接受了体外膜肺氧合-心肺复苏（Extracorporeal Membrane Oxygenation-Cardiopulmonary Resuscitation, ECMO-CPR）治疗。低龄（