Host Polymorphs and Crystalline Host–Guest Complexes of 3,3′-Bis(9-hydroxy-9-fluorenyl)biphenyl

The diol host compound 2 featuring a structure with
two 9-fluorenol moieties attached in 3,3′-position to a biphenyl
core unit has been synthesized and is shown to form crystalline inclusion
complexes with organic guest molecules. Aside from the single-crystal
X-ray structures of unsolvated 2 in two polymorphous
forms (2A, 2B), structures of five inclusion
compounds with 1,4-dioxane (2a), DMSO (2b), diethylamine (2c), acetic acid (2d),
and ethyl acetate (2e) are described and comparatively
discussed in the interaction behavior including corresponding host
compounds with different attachment mode of the biphenyl unit and
the diphenylhydroxymethyl-substituted equivalent.

本研究合成了一种二醇类主体化合物2，其结构为联苯基（biphenyl）核心单元的3,3′位连接两个9-芴醇（9-fluorenol）基团，该化合物可与有机客体分子形成结晶型包结配合物。除解析得到两种多晶型形式（2A、2B）的无溶剂化化合物2的单晶X射线衍射结构外，本研究还报道了该主体与五种客体分子形成的包结配合物结构，分别为与1,4-二氧六环（1,4-dioxane）形成的2a、与二甲基亚砜（DMSO）形成的2b、与二乙胺（diethylamine）形成的2c、与乙酸（acetic acid）形成的2d以及与乙酸乙酯（ethyl acetate）形成的2e，并从相互作用行为层面开展对比讨论，同时涵盖了联苯基单元连接方式存在差异的对应主体化合物，以及二苯羟甲基取代的同类主体化合物。