NSCR_Dataset_2020

The University of Turin (UniTO) released the open-access dataset NSCR_Dataset collected for the NEUROSTEMCELLREPAIR (602278) and NSC-Reconstruct (874758) European stem cell consortia for neural cell replacement, reprogramming and functional brain repair (602278) (https://www.nsc-reconstruct.com/en/index.do). NSCR-Dataset is a dataset of analysis of histological ex-vivo brain samples and behavioral parameters from Huntington's Disease (HD) rat models, after cell replacement approach of striatal progenitor cells at the site of grafting - the striatum, at different time point (see for details at short time-points: https://www.sciencedirect.com/science/article/pii/S2213671120301089?via%3Dihub). The UniTO team released this dataset publicly. The dataset contains images of brain tissue stained for different cellular and molecular markers, acquired with transmission and confocal microscopes, from which analysis were performed, and the behavioral data obtained every month by testing the HD animals in different motor tasks. High-resolution images have been acquired; the images will be made available.都灵大学（University of Turin, UniTO）发布了开源数据集NSCR_Dataset，该数据集是为欧洲神经干细胞修复（NEUROSTEMCELLREPAIR，项目编号602278）与NSC-Reconstruct（项目编号874758）两大干细胞联盟开展神经细胞替代、重编程及功能性脑修复研究（项目编号602278）而收集的，相关项目官网为https://www.nsc-reconstruct.com/en/index.do。 NSCR-Dataset数据集聚焦亨廷顿舞蹈症（Huntington's Disease, HD）大鼠模型的离体（ex-vivo）脑组织样本组织学分析与行为学参数记录，其实验干预为在移植位点——纹状体（striatum）——植入纹状体祖细胞（striatal progenitor cells），并在不同时间点开展后续观测（短期时间点细节可参考：https://www.sciencedirect.com/science/article/pii/S2213671120301089?via%3Dihub）。该数据集由都灵大学团队公开发布。 本数据集包含通过透射显微镜（transmission microscopes）与共聚焦显微镜（confocal microscopes）采集的、针对不同细胞与分子标志物染色的脑组织图像，以及通过每月对HD模型大鼠开展不同运动功能任务测试得到的行为学数据。 本数据集已完成高分辨率图像采集，相关图像将公开发布。