Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients

The alpha2 agonist dexmedetomidine is a new sedative agent combined with the analgesic qualities and lack of respiratory depression. Patients sedated with dexmedetomidine could be easily roused, these advances shows dexmedetomidine may be a effective and safe sedative agent. But some studies showed some adversely effects of dexmedetomidine on haemodynamics (such as bradycardia, hypotension), the investigators want to further research the effects of dexmedetomidine on haemodynamics, such as Cardiac Output (CO), Systemic Venous Resistance Index(SVRI), and so on. Propofol is widely used sedative agent in ICU, it also has adversely effects like bradycardia and hypotension, so the investigators want to compare the effect of dexmedetomidine with propofol on haemodynamics after major abdominal surgery. Expect to further research the mechanism of haemodynamics of dexmedetomidine.

α2肾上腺素能受体激动剂（alpha2 agonist）右美托咪定（dexmedetomidine）是一种兼具镇痛功效且无呼吸抑制作用的新型镇静药物。采用右美托咪定镇静的患者可被轻易唤醒，上述优势表明右美托咪定或为一种安全有效的镇静药物。但已有研究显示，右美托咪定对血流动力学存在部分不良影响，例如心动过缓、低血压。本研究团队拟进一步探究右美托咪定对血流动力学的影响，包括心输出量（Cardiac Output，CO）、体循环静脉阻力指数（Systemic Venous Resistance Index，SVRI）等指标。丙泊酚（Propofol）是重症监护病房（ICU）中广泛应用的镇静药物，同样可引发心动过缓、低血压等不良反应。因此本研究团队拟对比腹部大手术后，右美托咪定与丙泊酚对患者血流动力学的影响，以期进一步阐明右美托咪定对血流动力学的作用机制。