Meta analysis related results.

Objective
The purpose of this study is to investigate the relationship between single nucleotide polymorphisms of inflammatory cytokines and neonatal sepsis through meta-analysis.
Methods
We collected research literature on the correlation between inflammatory cytokine polymorphisms and neonatal sepsis published before August 2023 through computer searches of databases such as PubMed, Embase, etc. The Stata 14.0 software was utilized for Meta-analysis. To assess heterogeneity, the chi-squared Q-test and I2 statistics were used. The Egger and Begg tests were conducted to determine the possibility of publication bias.
Results
After reviewing 1129 articles, 29 relevant articles involving 3348 cases and 5183 controls were included in the study. The meta-analysis conducted on IL-1βrs1143643 polymorphism revealed significant findings: the T allele genotype has a lower risk of neonatal sepsis(P = 0.000, OR = 0.224, 95% CI: 0.168–0.299), while the TC and TT genotypes showed an increased risk(TC: P = 0.000,OR = 4.251, 95% CI: 2.226–8.119; TT: P = 0.019,OR = 2.020, 95% CI: 1.122–3.639). Similarly, newborns with the IL-6-174 CC genotype had a significantly higher risk of sepsis(P = 0.000,OR = 1.591, 95% CI: 1.154–2.194), while those with the IL-8-rs4073 TT (P = 0.003,OR = 0.467, 95% CI: 0.280–0.777)and TT + AA(P = 0.003,OR = 0.497, 95% CI: 0.315–0.785) genotypes had a significantly lower risk of sepsis. For the IL-10-1082 gene, newborns with the AA genotype(P = 0.002,OR = 1.702, 95% CI: 1.218–2.377), as well as those with the AA + GA genotype(P = 0.016,OR = 1.731, 95% CI: 1.108–2.705), had a significantly higher risk of sepsis. Lastly, newborns carrying the TNF-α–308 A allele (P = 0.016,OR = 1.257, 95% CI: 1.044–1.513)or the AA genotype(P = 0.009,OR = 1.913, 95% CI: 1.179–3.10) have a significantly increased risk of sepsis. Notwithstanding, additional studies must be included for validation. Applying these cytokines in clinical practice and integrating them into auxiliary examinations facilitates the early detection of susceptible populations for neonatal sepsis, thereby providing a new diagnostic and therapeutic approach for neonatal sepsis.

研究目的
本研究旨在通过荟萃分析（meta-analysis）探讨炎症细胞因子单核苷酸多态性与新生儿脓毒症之间的关联。
研究方法
本研究通过计算机检索PubMed、Embase等数据库，收集2023年8月前发表的关于炎症细胞因子多态性与新生儿脓毒症相关性的研究文献。采用Stata 14.0软件开展荟萃分析，使用卡方Q检验与I²统计量评估研究异质性，通过Egger检验及Begg检验判断发表偏倚的可能性。
研究结果
本研究共检索到1129篇文献，最终纳入29篇相关文献，涉及3348例病例组受试者与5183例对照组受试者。针对IL-1β rs1143643多态性的荟萃分析结果显示：T等位基因基因型可降低新生儿脓毒症发病风险（P=0.000，OR=0.224，95%CI：0.168~0.299），而TC、TT基因型则会升高发病风险（TC：P=0.000，OR=4.251，95%CI：2.226~8.119；TT：P=0.019，OR=2.020，95%CI：1.122~3.639）。类似地，携带IL-6-174 CC基因型的新生儿脓毒症发病风险显著升高（P=0.000，OR=1.591，95%CI：1.154~2.194）；而携带IL-8 rs4073 TT基因型（P=0.003，OR=0.467，95%CI：0.280~0.777）及TT+AA基因型（P=0.003，OR=0.497，95%CI：0.315~0.785）的新生儿脓毒症发病风险则显著降低。对于IL-10-1082基因，携带AA基因型（P=0.002，OR=1.702，95%CI：1.218~2.377）及AA+GA基因型（P=0.016，OR=1.731，95%CI：1.108~2.705）的新生儿脓毒症发病风险显著升高。最后，携带TNF-α-308 A等位基因（P=0.016，OR=1.257，95%CI：1.044~1.513）或AA基因型（P=0.009，OR=1.913，95%CI：1.179~3.10）的新生儿脓毒症发病风险显著升高。尽管如此，仍需开展更多研究以验证上述结论。将上述细胞因子应用于临床实践并纳入辅助检查，有助于早期识别新生儿脓毒症易感人群，从而为新生儿脓毒症提供全新的诊疗思路。