Lecanemab binds to transgenic mouse model-derived amyloid-β fibril structures resembling Alzheimer´s disease type-I, type-II and Arctic folds

Immunogold electron microscopy of lecanemab-bound amyloid-beta fibrils from transgenic mouse models of Alzheimer's disease Mouse models: tg-APPArcSwe APP23 tg-APPSwe APP/PS1 ARTE10 tg-SwDI All micrographs utilized for the co-localization analysis of lecanemab binding to amyloid-β fibrils are compiled in the file ig_tem_mic_lecanemab_Ab_fibrils_coloc.tar. All electron micrographs presented in Figure 1 of the manuscript can be accessed in the file ig_tem_mic_lecanemab_Ab_fibrils_Fig1.tar.阿尔茨海默病转基因小鼠模型来源的与仑卡奈单抗（lecanemab）结合的β淀粉样蛋白原纤维的免疫金电子显微镜成像 实验所用小鼠模型： tg-APPArcSwe APP23 tg-APPSwe APP/PS1 ARTE10 tg-SwDI 用于仑卡奈单抗与β淀粉样蛋白原纤维结合共定位分析的所有显微图像，均打包收录于文件ig_tem_mic_lecanemab_Ab_fibrils_coloc.tar中。 本研究手稿图1中展示的所有电子显微图像，可从文件ig_tem_mic_lecanemab_Ab_fibrils_Fig1.tar中获取。