Urine sample

The Netherlands Twin Register (NTR) consists of individuals who have agreed to participate in twin-family studies and was established and is managed by the Department of Biological Psychology, VU University Amsterdam (see: https://tweelingenregister.vu.nl/). The NTR was established in 1987 and has enrolled around 120.000 twins and a roughly equal number of their relatives. The majority of twin families have participated one or more times in survey studies on a host of epidemiological variables including social demography, personality, lifestyle, somatic and mental health, and subsamples took part in biomaterial collection (e.g. DNA) and dedicated projects for e.g. neuropsychological, biomarker, and behavioral traits. The recruitment into the NTR is fully inclusive without any restrictions on enrolment. The NTR is committed to actively seek the commitment of its participants to science and their continued involvement in NTR research by maintaining a website, electronic newsletters, and the MijnNTR portal that provides personalized feedback to participants. The NTR resources, e.g. the longitudinal phenotyping, the extended pedigree structures, and the multi-generation genotyping allow for future twin-family research that will contribute to gene discovery, causality modelling, and studies of genetic and cultural inheritance of behavioral traits and mental and physical health. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR).

荷兰双生子登记库（Netherlands Twin Register, NTR）由自愿参与双生子家庭研究的个体组成，由阿姆斯特丹自由大学生物心理学系建立并管理（详见：https://tweelingenregister.vu.nl/）。该登记库于1987年成立，目前已招募约12万名双生子及数量相近的亲属。多数双生子家庭曾参与一项或多项针对多类流行病学变量的调查研究，涵盖社会人口学特征、人格特质、生活方式、躯体与精神健康等领域；部分子样本参与了生物样本采集（如DNA样本）及针对神经心理学、生物标志物、行为特征等的专项研究。NTR的招募完全开放，无入组限制。该登记库通过维护官方网站、电子通讯刊物，以及为参与者提供个性化反馈的MijnNTR门户，积极吸引参与者投身科研并持续参与NTR的研究工作。NTR拥有的各类资源——例如纵向表型采集体系、扩展家系结构、多代基因分型数据——可为未来的双生子家庭研究提供支撑，助力基因发现、因果关系建模，以及行为特征与精神、躯体健康的遗传和文化遗传相关研究。在CID数据目录中，仅纳入了针对儿童及青少年（<18岁）的NTR相关项目，该子库被称为荷兰青年双生子登记库（Young Netherlands Twin Register, YNTR）。