Data of mRNA and protein abundances of androgen receptor splice variants in castration-resistant prostate cancer

R scripts (.R files) and raw data of splicing junction (SJ) reads from 34 CRPC adenocarcinoma samples in the Beltran cohort, 81 CRPC samples in the Prostate Cancer Medically Optimized Genome-Enhanced Therapy (PROMOTE) cohort, and 181 CRPC samples in the Stand Up To Cancer (SU2C) cohort are indicated by individual file names. "Figure 3_quantitation.xlsx" is the RT-qPCR raw data of the ratios of AR-V7 to AR-FL mRNA in LNCaP95 cells cultured in androgen-deprived or -replenished condition as well as in hormone-sensitive and castration-resistant LuCaP 35 and 96 PDXs. "Figure 4_Western blots.pptx" is the Western Blotting raw data of the ratios of AR-V7 to AR-FL protein in these cells and PDXs. "Figure 4_quantitation.xlsx" is the quantitation data of the " Figure 4_Western blots.pptx".

本数据集包含Beltran队列中34例去势抵抗性前列腺癌（castration-resistant prostate cancer, CRPC）腺癌样本、前列腺癌医学优化基因组增强治疗（Prostate Cancer Medically Optimized Genome-Enhanced Therapy, PROMOTE）队列中81例CRPC样本以及Stand Up To Cancer（SU2C）队列中181例CRPC样本的剪接接头（splicing junction, SJ）读段原始数据与R脚本（.R文件），各类数据均以独立文件名标识。"Figure 3_quantitation.xlsx" 包含在雄激素剥夺或雄激素补充培养条件下的LNCaP95细胞，以及激素敏感型和去势抵抗型LuCaP 35、LuCaP 96患者来源的异种移植模型（patient-derived xenograft, PDX）中，雄激素受体剪接变异体7（AR-V7）与全长雄激素受体（AR-FL）信使核糖核酸（messenger ribonucleic acid, mRNA）的比值的逆转录实时定量聚合酶链反应（RT-qPCR）原始数据。"Figure 4_Western blots.pptx" 包含前述细胞及PDX模型中AR-V7与AR-FL蛋白质比值的蛋白质印迹（Western Blotting）原始数据。"Figure 4_quantitation.xlsx" 为"Figure 4_Western blots.pptx"的定量分析数据。