Gene expression signature and the prediction of lymph node metastases

Samples were taken from colorectal cancers in surgically resected specimens in 89 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be used for molecular markers for predicting lymph node metastases. Keywords: disease state analysis Eighty-nine colorectal cancer patients were studied. Samples from 89 patients were divided into a training set (69 samples) and a testing set (20 samples).

本研究从89例结直肠癌患者的手术切除标本中获取结直肠癌组织样本。采用Affymetrix Human Genome U133 Plus 2.0 基因芯片检测样本的基因表达谱。通过对各组样本的比较分析，可鉴定出一组判别基因，该组基因可作为预测淋巴结转移的分子标志物。
关键词：疾病状态分析
本研究共对89例结直肠癌患者进行了研究，其样本被划分为训练集（69例样本）与测试集（20例样本）。