Targeting of mitochondrial Hsp90 with Gamitrinib, G-TPP, in U251 glioblastoma cells

ChEBI2010-12-28 更新2026-07-21 收录

抗肿瘤研究

胶质瘤靶向治疗

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Targeting of mitochondrial Hsp90 with Gamitrinib, G-TPP, in U251 glioblastoma cells

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2010-12-28

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity

GLS1抑制剂开发

抗肿瘤研究

This study evaluates LX-191, a wogonin-derived glutaminase-1 (GLS1) inhibitor featuring a non-BPTES chemotype, designed to overcome the limitations of existing GLS1-targeted therapies. Following targ

NIAID Data Ecosystem110

Identification and validation of GPD1 as an essential cancer stem cell specific target in glioblastoma (RNA-seq: Gpd1 KO). Identification and validation of GPD1 as an essential cancer stem cell specific target in glioblastoma (RNA-seq: Gpd1 KO)

胶质瘤靶向治疗

癌症干细胞休眠调控

Cancer stem cells (CSCs) are attractive targets for cancer therapy, however, little is known about how to target CSCs without affecting the normal stem cell population. Here we report the ribosome-pro

NIAID Data Ecosystem70

Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial 1 homeostasis and increases antitumor activity against glioblastoma

胶质瘤靶向治疗

线粒体功能与细胞稳态

Background: Few druggable targets have been discovered in glioblastoma (GBM); however, increasing knowledge has uncovered two hallmarks of this disease: epigenetic modifications and cell cycle dysregu

NIAID Data Ecosystem20

Additional file 13 of Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma

胶质瘤靶向治疗

铜死亡机制研究

Additional file 13.

DataCite Commons2024-08-18 更新90

Evaluation of Tyrosine Kinase Inhibitor Combinations for Glioblastoma Therapy

胶质瘤靶向治疗

酪氨酸激酶抑制剂组合疗效

Glioblastoma multiforme (GBM) is the most common intracranial cancer but despite recent advances in therapy the overall survival remains about 20 months. Whole genome exon sequencing studies implicate

Figshare2016-01-19 更新20

Targeting of mitochondrial Hsp90 with Gamitrinib, G-TPP, in U251 glioblastoma cells

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