Liver organoids generated from individuals carrying PiZZ variant of alpha-1-antitrypsin contain high lipid content

We generated hepatic organoids from MZ and ZZ patients with the aim to investigate their lipid status To discover genes related to lipid metabolism likely involved in lipid deposits. Comparative gene expression analysis of RNA-seq data of hepatic organoids derived from alpha-1 antitrypsin deficiency

我们从携带MZ、ZZ基因型的患者中构建肝脏类器官（hepatic organoids），旨在探究其脂质代谢状态，并筛选与脂质沉积相关的脂质代谢调控基因。随后对源自α1-抗胰蛋白酶缺乏症（alpha-1 antitrypsin deficiency）患者的肝脏类器官的RNA测序（RNA-seq）数据开展比较基因表达分析。