Study population.

This study aimed to analyze the association between functional status, biomarkers, and hospitalization characteristics on costs and the probability of re-admission at 30 and 180 days in geriatric patients. It is used an observational design with both administrative data and additional clinical data not usually collected. Multivariate linear regression for hospitalization costs and multivariate logistic regressions for readmissions were used. Variables studied included the Barthel Index, Charlson index, albumin and blood pressure levels, previous hospitalizations, length of stay (LoS), and controls. Data from 953 patients aged over 65, admitted to the Geriatric ward between September 1st, 2018, and December 31st, 2019, were analyzed. The Charlson comorbidity index, number of comorbidities, and LoS were positively related to hospitalization costs. Previous hospitalizations and LoS were the main predictors of readmission. Systolic blood pressure was negatively associated with the odds of re-admission but showed no association with hospital costs. Higher functional status, as measured by the Barthel index, was linked to lower odds of unplanned hospitalization but was not statistically significant for costs. Functional status and biomarkers had moderate effects on costs and readmission odds. These findings can aid in early healthcare planning and resource management, providing valuable information for prioritizing patients and designing cost-effective care interventions.本研究旨在分析老年患者的功能状态、生物标志物与住院特征对住院费用及30天、180天再入院概率的关联。本研究采用观察性研究设计，整合常规行政数据与非常规收集的补充临床数据。针对住院费用采用多元线性回归分析，针对再入院情况采用多元逻辑回归分析。所纳入的研究变量包括巴氏指数（Barthel Index）、查尔森合并症指数（Charlson Comorbidity Index）、白蛋白水平、血压水平、既往住院史、住院时长（Length of Stay, LoS）以及对照变量。本研究分析了2018年9月1日至2019年12月31日期间收治于老年科的953名65岁以上患者的数据。研究结果显示：查尔森合并症指数、合并症数量与住院时长均与住院费用呈正相关；既往住院史与住院时长是再入院的主要预测因子；收缩压与再入院的比值比呈负相关，但与住院费用无显著关联。通过巴氏指数衡量的更高功能状态与更低的非计划住院风险相关，但对住院费用无统计学显著影响。功能状态与生物标志物对住院费用及再入院比值比具有中等程度的影响。本研究结果可助力早期医疗规划与资源管理，为患者优先级划分及设计具有成本效益的照护干预措施提供有价值的参考信息。