Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase

The aim of the study was to evaluate the feasibility of TS determination in a multicenter trial setting using a central facility for measurement and confirm its role as predictive factor for 5-FU treatment in MCRC.

本研究旨在评估多中心临床试验场景下，采用中央检测机构开展TS（Thymidylate Synthase，胸苷酸合成酶）检测的可行性，并验证其作为5-氟尿嘧啶（5-Fluorouracil，5-FU）治疗转移性结直肠癌（MCRC）的预测因子的作用。