ATN 071 Activities of Daily Living: Taking/Keeping Track of Medication Dataset in Neurocognitive Assessment in Youth Initiating HAART

Data from Activities of Daily Living: Taking/Keeping Track of Medication [CRF f16med]
Study Description
A prospective cohort study comparing neurocognitive functioning in four groups of youth, ages 18-24 years, with behaviorally acquired HIV infection: two groups with CD4+ T-cells greater than 350 cells/mm3 and HIV RNA equal to or greater than 1,000 copies/ml - one initiating early highly active antiretroviral therapy (HAART) (Group 1), the other not initiating treatment (Group 2); and two groups with CD4+ T-cells less than 350 cells/mm3 - one initiating HAART according to then current DHHS guidelines (Group 3), the other not initiating treatment (Group 4). Groups 2 and 3 represented standard of care. The study provided preliminary data to test the hypothesis that initiating HAART earlier than DHHS guidelines suggested at that time resulted in better neurocognitive function in comparison with no treatment or treatment initiated according to DHHS recommendations. Youth ages 18-24 years with behaviorally acquired HIV infection

日常活动数据：服药/用药追踪 [病例报告表（Case Report Form）f16med]
研究概况
本研究为一项前瞻性队列研究，旨在对比4组18至24岁行为获得性人类免疫缺陷病毒（Human Immunodeficiency Virus, HIV）感染青年的神经认知功能。该4组研究对象分为两类：
1. CD4+T淋巴细胞计数＞350个/mm³且人类免疫缺陷病毒核糖核酸（HIV RNA, Human Immunodeficiency Virus Ribonucleic Acid）≥1000拷贝/mL的两组：一组早期启动高效抗反转录病毒治疗（Highly Active Antiretroviral Therapy, HAART）（第1组），另一组未启动治疗（第2组）；
2. CD4+T淋巴细胞计数＜350个/mm³的两组：一组按照当时美国卫生与人类服务部（Department of Health and Human Services, DHHS）指南启动HAART治疗（第3组），另一组未启动治疗（第4组）。
其中第2组与第3组代表当时的标准治疗方案。
本研究通过采集初步数据，验证了如下假说：相较于未接受治疗，或按照当时DHHS指南推荐启动HAART治疗的人群，提前启动HAART治疗可获得更优的神经认知功能。
本研究的研究对象为18至24岁行为获得性HIV感染青年。