An evaluation of homocysteine, C-reactive protein, lipid levels, neutrophils to lymphocyte ratio in postmenopausal osteopenic women

<i>Objective</i>: In the present study, the risk coefficients of serum homocysteine (hcy), lipid levels, C-reactive protein (CRP), neutrophils to lymphocyte ratio (NLR) in postmenopausal osteopenic women were determined. <i>Methods</i>: We enrolled 269 patients with postmenopausal women from Hangzhou No.1 Hospital gynecological clinic, who aged 45 to 60 years old and never received menopause hormone therapy. According to the bone mineral density determination results, subjects were divided into normal group (<i>n</i> = 128), osteopenia group (<i>n</i> = 141). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA). Serum hcy, CRP and lipid indexes were determined by enzyme chemiluminescence immunoassay. <i>Results</i>: The odds ratios (OR) and 95% confidence intervals (CI) of those variables (menopausal age, duration of menopause, LDL, CRP, hcy and NLR) were found significant (<i>p</i> <i>Conclusion</i>: The present study shows that menopause age, duration of menopause, serum LDL, CRP, hcy and NLR levels are risk factors for postmenopausal osteopenic women, which may be used as the indicators of bone loss in postmenopausal women.

<i>研究目的</i>：本研究旨在明确绝经后骨量减少女性的血清同型半胱氨酸（homocysteine, Hcy）、血脂水平、C反应蛋白（C-reactive protein, CRP）以及中性粒细胞与淋巴细胞比值（neutrophils to lymphocyte ratio, NLR）的风险系数。
<i>研究方法</i>：本研究招募杭州市第一医院妇科门诊的269名绝经后女性作为研究对象，年龄介于45至60岁之间，且均未接受过绝经激素治疗。根据骨密度检测结果，将受试者分为骨量正常组（n=128）与骨量减少组（n=141）。采用双能X线吸收法（dual-energy X-ray absorptiometry, DXA）检测骨密度（bone mineral density, BMD），通过酶化学发光免疫分析法测定血清同型半胱氨酸、C反应蛋白及血脂相关指标。
<i>研究结果</i>：上述变量（绝经年龄、绝经时长、低密度脂蛋白、C反应蛋白、同型半胱氨酸及中性粒细胞与淋巴细胞比值）的比值比（odds ratios, OR）与95%置信区间（95% confidence intervals, CI）均具有统计学显著性（p<）。
<i>研究结论</i>：本研究结果表明，绝经年龄、绝经时长、血清低密度脂蛋白、C反应蛋白、同型半胱氨酸及中性粒细胞与淋巴细胞比值均为绝经后骨量减少女性的危险因素，可作为绝经后女性骨量丢失的监测指标。