POPULATION AVERAGE UNICORONAL CRANIOSYNOSTOSIS SKULL

Nineteen patients having UC were recruited at GOSH (age 9.8+/-4.1): DICOM images were collected, converted into skull 3D STL files using Simpleware ScanIP (Synopsys®) and processed using Meshmixer (Autodesk®). A standard geometric morphometric protocol was used for 3D shape processing: each model was cut along the Frankfurt plane and the outer surface of the skull was extracted. A template mesh was used and no-rigid iterative closest point registration (implemented in Matlab) was used to achieve a common discretisation for each model. A population average model was created by averaging node coordinates.

本研究在大奥蒙德街儿童医院（Great Ormond Street Hospital，GOSH）招募了19名溃疡性结肠炎（Ulcerative Colitis，UC）患者，受试者年龄为9.8±4.1岁：收集其DICOM（数字成像与通信医学，Digital Imaging and Communications in Medicine）影像后，通过Simpleware ScanIP（Synopsys®）将其转换为颅骨3D STL文件，并使用Meshmixer（Autodesk®）完成处理。采用标准几何形态测量学协议开展3D形状处理：将每个模型沿法兰克福平面裁切，并提取颅骨外表面。使用模板网格，并借助Matlab实现的非刚性迭代最近点配准，为所有模型实现统一的离散化处理。通过对各模型的节点坐标取平均，构建群体平均模型。