Analysis of Approaches to Anti-tuberculosis Compounds

Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after
the announcement
of tuberculosis (TB) as a global health emergency by the World Health
Organization. Medicinal chemistry efforts to synthesize potential
drugs to shorten TB treatments have not always been successful. Here,
we analyze physiochemical properties of 39 TB drugs and 1271 synthetic
compounds reported in 40 publications from 2006 to early 2020. We
also propose a new TB space of physiochemical properties that may
provide more appropriate guidelines for design of anti-TB drugs.

自世界卫生组织（World Health Organization）将结核病（Tuberculosis, TB）列为全球卫生紧急事件至今已有二十载，结核分枝杆菌（Mycobacterium tuberculosis, Mtb）仍是极具威胁的致命病原体。为缩短结核病治疗周期而合成潜在抗结核药物的药物化学研究并非总能取得成功。本研究针对2006年至2020年初期间40篇已发表文献中报道的39种抗结核药物及1271种合成化合物的理化性质展开分析。此外，本研究还提出了一套全新的结核病相关理化性质空间框架，可为抗结核药物的分子设计提供更为适配的指导准则。