Structure of human endothelial nitric oxide synthase heme domain in complex with (S)-3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)propyl)benzonitrile
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Structure of human endothelial nitric oxide synthase heme domain in complex with (S)-3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)propyl)benzonitrile Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, ... Authors: Chreifi, G, Li, H, Poulos, T.L. Deposit date: 2017-01-31 Release date: 2017-05-03 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. J. Med. Chem., 60, 2017
人类内皮型一氧化氮合酶血红素结构域与(S)-3-[(2-氨基-4-甲基喹啉-7-基)甲氧基]-5-(2-(甲氨基)丙基)苯甲腈形成的复合物结构 描述符：2-[双(2-羟乙基)氨基]-2-羟甲基丙烷-1,3-二醇、3-[(2-氨基-4-甲基喹啉-7-基)甲氧基]-5-[(2S)-2-(甲氨基)丙基]苯甲腈、5,6,7,8-四氢生物蝶呤，…… 作者：Chreifi, G、Li, H、Poulos, T.L. 入库日期：2017-01-31 发布日期：2017-05-03 最后修改日期：2023-10-04 实验方法：X射线衍射（2.2 Å） 引用文献：《孔穴中的腈类：神经元型一氧化氮合酶中一处小型辅助口袋的发现助力强效选择性2-氨基喹啉类抑制剂的开发》，J. Med. Chem.，60，2017
