Proteome database of Hafnia alvei FB1

Hafnia alvei is a Gram-negative, facultative anaerobic
bacterium that is part of the gut microbiota. Resistant to a few antibiotics,
the bacterium is increasingly recognized as an opportunistic pathogen,
particularly with respect to the immunocompromised. This work sought to shed light
on the proteome of H. alvei through parsing the UniProt proteome file of
H. alvei FB1 using an in-house MATLAB proteome analysis software.
Altogether, protein name, amino acid sequence, number of residues are extracted
into a proteome database of the organism. The database is further augmented by
the calculation of molecular weight and nucleotide sequence of each protein in
the proteome of H. alvei. Overall, the proteome information provided in
this database should find use in understanding the molecular effectors that are
postulated to participate in the pathogenesis process, as well as guiding
molecular cloning and genome editing efforts in understanding the functional
roles of particular proteins in the bacterium.

蜂房哈夫尼菌（Hafnia alvei）是一种革兰氏阴性兼性厌氧菌，隶属于肠道微生物群。该菌对少数抗生素具有耐药性，现已日益被认定为一种机会致病菌，尤其在免疫功能受损人群中更为突出。本研究旨在阐明蜂房哈夫尼菌的蛋白质组：通过自研MATLAB蛋白质组分析软件，解析蜂房哈夫尼菌FB1的通用蛋白质资源数据库（UniProt）蛋白质组文件。最终，我们提取了该菌体的蛋白质名称、氨基酸序列与残基数量，构建了该菌的蛋白质组数据库。后续通过计算该菌蛋白质组中各蛋白质的分子量与核苷酸序列，进一步扩充完善了该数据库。总体而言，本数据库所收录的蛋白质组信息，既可用于解析被推测参与致病过程的分子效应因子，也可为分子克隆与基因组编辑相关研究提供指导，以阐明该菌中特定蛋白质的功能角色。