DBL-1 Pathway Modulates Dauer Constitutive Phenotype of <i>daf-2</i> Mutants at 20°C.

In an otherwise wild-type background, DBL-1 signaling exerts no visible effect on dauer induction at both 20°C and 25°C. However, in a DAF-2-sensitized background, DBL-1 signaling promotes dauer arrest at 20°C. This effect is lost when observed at 25°C, where the loss of DAF-2 signaling is most potent. Values given are percent arrested dauer-like larvae of total progeny ± SEM.在常规野生型背景中，DBL-1信号通路在20℃与25℃条件下对dauer诱导均未产生可见影响。然而在DAF-2敏化背景中，DBL-1信号通路可在20℃条件下促进dauer滞育停滞。当实验在25℃条件下开展时，该促进效应消失；而25℃正是DAF-2信号通路缺失效应最为显著的实验条件。本次报告的数值为类dauer幼虫占总后代的百分比 ± 标准误（standard error of the mean, SEM）。