MOESM4 of Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

Additional file 4. Linkage disequilibrium (LD) analysis of all high frequency (>5%) SNPs in all 15 merozoite genes, except eba181 due to limited SNP data. The analysis was performed by conducting all possible pair-wise comparisons between all the SNPs across 14 merozoite genes using a pair-wise correlation analysis and a Bonferroni correction for multiple comparisons. The red boxes represent significant correlations between SNPs and thus SNPs in LD, orange represents correlations between SNPs that are not significant, white indicates the SNPs that are not correlated and therefore they are not in LD and grey represents cases where the SNP data is missing in one or both of the paired SNPs.

补充文件4：针对15个裂殖子基因中所有等位基因频率大于5%的单核苷酸多态性（Single Nucleotide Polymorphism, SNPs）开展连锁不平衡（Linkage Disequilibrium, LD）分析，因单核苷酸多态性数据量有限，排除eba181基因。本次分析针对14个裂殖子基因内的全部单核苷酸多态性位点，开展所有可能的两两比对，采用两两相关分析方法，并针对多重比较进行邦费罗尼（Bonferroni）校正。其中，红色框代表单核苷酸多态性位点间存在显著相关，即二者处于连锁不平衡状态；橙色框代表位点间相关不显著；白色代表位点间无相关，即未处于连锁不平衡；灰色则代表配对的两个单核苷酸多态性位点中，一个或两个均缺失数据的情况。