RBMS1 regulates lung cancer progression

In order to profile the translation events that were regulated by RBMS1, Ribo-seq was performed on A549 cells which was used to generate RBMS1 stably depleted and overexpressed lung cancer cells. This study includes a total of 5 ribosome footprint profiling samples, A549_sh1196 and A549_sh1088 was generated as a RBMS1 stably depleted A549 lung cancer cells. A549_R1A was generated as a RBMS1 stably overexpressed A549 lung cancer cells .

为解析受RBMS1调控的翻译事件，本研究对A549细胞开展核糖体印迹测序（Ribo-seq），并构建了RBMS1稳定敲低及稳定过表达的肺癌A549细胞模型。本研究共包含5组核糖体印迹测序样本，其中A549_sh1196与A549_sh1088为RBMS1稳定敲低的肺癌A549细胞系，A549_R1A为RBMS1稳定过表达的肺癌A549细胞系。