Additional file 1: of Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis

Table S1. Phenotype information of AS patient individuals and health controls in discovery stage (156 samples) and validation stage (55 samples). Table S2. Data production and quality control of 156 samples in discovery stage and 55 samples in validation stage. Table S3. The 8743 reference genomes from NCBI and HMP (downloaded on 15 Dec 2013). Table S4. The differentially abundant genus in AS patients (n = 73) and healthy controls (n = 83). Table S5. Assembly result of 156 samples in discovery stage. Table S6. The improvement with the repeatedly assembly. Table S7. Gene prediction of 156 samples in discovery stage. Table S8. Genes with abundance which belong to proteasome modules. All the differentially abundant genes identified in this study only belong to bacterial proteasome. Table S9. The taxonomic annotation of MGSs. Table S10. The phenotypic correlation analysis (p value) of 12 MGSs according to different clinical groups. Table S11. Comparison of the MGS in different diseases. Table S12. The taxonomic annotation of CAGs (Gene number ≥ 100). Table S13. The details of the best markers selected for five monitoring and classification models based on five kinds of bio-markers. Table S14. The 210 differentially abundant sequenced reference genome markers used for classification training. (XLSX 870 kb)

补充表S1：发现队列（156份样本）与验证队列（55份样本）中强直性脊柱炎（AS）患者及健康对照的表型信息
补充表S2：发现队列156份样本与验证队列55份样本的数据生成流程及质量控制结果
补充表S3：2013年12月15日下载自美国国家生物技术信息中心（NCBI）与人类微生物组计划（HMP）的8743条参考基因组序列
补充表S4：强直性脊柱炎患者（n=73）与健康对照（n=83）间差异丰度的菌属信息
补充表S5：发现队列156份样本的宏基因组组装结果
补充表S6：重复宏基因组组装的优化效果分析
补充表S7：发现队列156份样本的基因预测结果
补充表S8：隶属于蛋白酶体模块的丰度基因信息；本研究鉴定的所有差异丰度基因均仅属于细菌蛋白酶体家族
补充表S9：宏基因组物种（MGS，Metagenomic Species）的分类注释信息
补充表S10：12个宏基因组物种按不同临床分组开展的表型相关性分析（P值）结果
补充表S11：不同疾病队列中宏基因组物种的比较分析结果
补充表S12：基因数量≥100的共扩增基因组（CAG，Co-amplification Genomes）的分类注释信息
补充表S13：基于5类生物标志物构建的5种监测与分类模型所筛选的最优标志物详情
补充表S14：用于分类模型训练的210个差异丰度测序参考基因组标志物（XLSX格式，文件大小870 KB）