Functional Microbial Responses to Alcohol Abstinence in Patients with Alcohol Use Disorder

Excessive alcohol consumption is associated with hepatic steatosis and dysregulation of the gut microbiota in patients with alcohol use disorder. However, how gut microbiota responds when patients stop drinking has not been well studied. In this study, we use shotgun metagenomic sequencing to elucidate the alterations in the functional capacity of gut microbiota in patients with alcohol use disorder when they stop drinking for two-weeks.

过量饮酒与酒精使用障碍（Alcohol Use Disorder, AUD）患者的肝脂肪变性及肠道菌群失调显著相关。然而，目前针对该类患者戒酒之后肠道菌群的应答变化，尚未得到充分研究。本研究采用霰弹枪宏基因组测序（shotgun metagenomic sequencing）技术，旨在阐明酒精使用障碍患者在停止饮酒两周后，其肠道菌群功能潜能的改变特征。