Bone marrow-derived macrophages from a murine model of Sjögren's syndrome demonstrate an aberrant, inflammatory response to apoptotic cells

We report that bone marrow derived macrophages from our Sjögren's syndrome mouse model exhibit an elevated inflammatory response to both apoptotic cells and TLR stimuli according to RNA-Seq data and pathway anyalysis Bone marrow derived macrophages from our Sjögren's syndrome model and B6 controls were treated with apoptotic cells or CpG and changes in transcriptome were reported

本研究通过RNA测序（RNA-Seq）数据与通路分析，报道了本团队构建的干燥综合征（Sjögren's Syndrome）小鼠模型来源的骨髓源性巨噬细胞，对凋亡细胞与Toll样受体（TLR）刺激物均呈现增强的炎症应答。本研究对该干燥综合征模型小鼠与C57BL/6（B6）对照小鼠的骨髓源性巨噬细胞，分别施加凋亡细胞或CpG处理，并报道了其转录组的变化情况。