TGF-beta Sma/Mab signaling regulates a set of genes in oocytes associated with reproductive aging and another set in L4 associated with body size growth

Reproductive cessation is perhaps the earliest aging phenotypes humans experience. Similarly, C. elegans' reproduction ceases in mid-adulthood. Although somatic aging has been studied in both worms and humans, mechanisms regulating reproductive aging are not yet understood. Here we show that TGF-beta Sma/Mab activity regulates reproductive aging transcriptionally separable from its regulation of body size growth. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

生殖停止或许是人类所经历的最早的衰老表型之一。与此类似，秀丽隐杆线虫（C. elegans）的生殖活动会在成年中期停止。尽管学界已针对秀丽隐杆线虫与人类的体细胞衰老开展研究，但调控生殖衰老的具体机制仍未阐明。本研究证实，转化生长因子β（TGF-β）Sma/Mab通路活性可调控生殖衰老，且该调控过程与其调控机体体型生长的过程在转录层面相互分离。本超系列（SuperSeries）由以下所列的子系列（SubSeries）构成，请参阅各独立系列（Series）。