Data from: Effects of working-memory training on striatal dopamine release

Updating of working memory has been associated with striato-frontal brain
regions and phasic dopaminergic neurotransmission. We assessed raclopride
binding to striatal dopamine (DA) D2 receptors during a letter-updating
task and a control condition before and after 5 weeks of updating
training. Results showed that updating affected DA activity before
training and that training further increased striatal DA release during
updating. These findings highlight the pivotal role of transient neural
processes associated with D2 receptor activity in working memory.

工作记忆更新与纹状体-前额叶脑区以及相位性多巴胺神经传递存在密切关联。本研究在为期5周的工作记忆更新训练前后，分别于字母更新任务及对照条件下，检测了雷氯必利(raclopride)与纹状体多巴胺(DA)D2受体的结合情况。结果显示，训练前的工作记忆更新操作即可影响多巴胺活性，且经训练后，更新任务过程中的纹状体多巴胺释放水平进一步升高。上述研究结果凸显了与D2受体活性相关的瞬时神经过程在工作记忆中所发挥的关键作用。