Blood analysis reveals differences in innate inflammatory sensitivity between species. Blood analysis reveals differences in innate inflammatory sensitivity between species

Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from rabbit, pig, sheep, cow, chimpanzee, human, mice, rats, baboon, and rhesus. Overall design: We compared transcriptomes of resting and LPS-exposed blood from rabbit, pig, sheep, cow, chimpanzee, human, mice, rats, baboon, and rhesus.

脊椎动物对细菌脂多糖（lipopolysaccharide, LPS）这类促炎激动剂的应答存在显著差异，这使得利用动物模型研究人类脓毒症或炎症性疾病的工作变得复杂化。我们对兔、猪、绵羊、牛、黑猩猩、人、小鼠、大鼠、狒狒以及恒河猴的静息血液与LPS暴露血液的转录组进行了比较分析。整体实验设计：我们对兔、猪、绵羊、牛、黑猩猩、人、小鼠、大鼠、狒狒以及恒河猴的静息血液与LPS暴露血液的转录组进行了比较分析。