Silver Triflate and Palladium Acetate Co-catalyzed Reaction of <i>N</i>′-(2-Alkynylbenzylidene)hydrazide with <i>N</i>-Allyl Ynamide

A silver triflate and palladium acetate co-catalyzed reaction of N′-(2-alkynylbenzylidene)hydrazide with N-allyl ynamide is described, which generates 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-endo cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization.本文报道了三氟甲磺酸银（silver triflate）与乙酸钯（palladium acetate）共催化下，N′-(2-炔基苯亚甲基)酰肼与N-烯丙基炔酰胺的反应，该反应可生成2-氨基-H-吡唑并[5,1-a]异喹啉类化合物，产率良好至优异。该转化通过6-内环化、[3+2]环加成、3,3-σ迁移重排及芳构化过程高效进行。