Figure 4- DREADD Agonists Dose Responses

2-5 month old male and female mice in which hM3Dq signalling is activated on VGLUT3-expressing neurons null for VGLUT3. Mouse lines were treated with saline, clozapine, compound 21 or perlapine and assessed in locomotor boxes.

本数据集的研究对象为2~5月龄的雌雄VGLUT3基因敲除小鼠，此类小鼠可在其表达囊泡谷氨酸转运体3（vesicular glutamate transporter 3, VGLUT3）的神经元上激活hM3Dq信号通路。受试小鼠分别经生理盐水、氯氮平、化合物21及培拉平处理，并在运动活动箱中完成行为学评估。