Salinispora arenicola CNY011. Salinispora arenicola CNY011

Multiplexed sequencing for secondary metabolite discovery: the goal of this project is to generate draft genome sequences for 144 or more cultured marine actinomycetes. The focus is on the genus Salinispora, which has proven to be a rich source of unusual secondary metabolites. Multiple strains derived from different locations will provide opportunities to assess the secondary metabolome of a well-defined bacterial lineage and to better understand pathway evolution and how it generates structural complexity. This project provides a unique opportunity to apply genome-mining approaches to natural product discovery and to use population genomics to explore fundamental questions related to the ecology and evolution of bacteria.

用于次生代谢产物发现的多重测序研究：本项目的目标是为144株及以上已培养的海洋放线菌生成基因组草图序列。研究重点聚焦于盐孢菌属（Salinispora），该属已被证实是非常规次生代谢产物的丰富来源。从不同地理位置分离得到的多株菌株，将为评估某一界定清晰的细菌谱系的次生代谢组（secondary metabolome），以及深入解析其代谢通路演化与结构复杂性的产生机制提供宝贵契机。本项目为将基因组挖掘（genome-mining）方法应用于天然产物发现，以及借助群体基因组学（population genomics）探究与细菌生态学及演化相关的基础科学问题，提供了独特的研究机遇。