WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Bulk RNA-seq heart left ventricle data from wild type and WWP2 gene mutant mice (after 28 days of angiotensinII treatment) Overall design: We generated WWP2 mutant mice using CRISPR/Cas9 technology to introduce a 4-bp deletion in exon 2. We treated these mutant and wild type mice with angiotensin II infusion for 28 days and harvested left ventricle heart tissue to carry out bulk RNA-sequencing.

野生型与WWP2基因（WWP2 gene）突变小鼠在血管紧张素II（angiotensin II）处理28天后的心脏左心室批量RNA测序（bulk RNA-seq）数据集。整体实验设计：本研究通过CRISPR/Cas9技术在小鼠WWP2基因第2外显子中引入4 bp缺失，构建WWP2基因（WWP2 gene）突变小鼠；随后对该突变小鼠与野生型小鼠开展为期28天的血管紧张素II灌注处理，并收集其心脏左心室组织进行批量RNA测序实验。