Transcriptome profiling of Mantle Cell Lymphoma and healthy controls using RNA-seq

The aim of this study was to profile transcriptome data, in particular circRNA expression, in lymph node tumour specimens from patients with Mantle Cell Lymphoma at diagnosis We performed total RNA sequencing using total RNA from lymph node tumour specimens of 14 patients with MCL, total RNA from two reactive lymph node specimens from healthy controls, and total RNA isolated from Naive B cells of peripheral blood of four healthy controls.

本研究旨在对初诊套细胞淋巴瘤（Mantle Cell Lymphoma, MCL）患者的淋巴结肿瘤组织标本开展转录组谱分析，重点聚焦环状RNA（circRNA）的表达特征。本研究利用14例MCL患者的淋巴结肿瘤组织总RNA、2例健康对照者的反应性淋巴结组织总RNA，以及4名健康对照者外周血初始B细胞（naive B cells）中分离得到的总RNA，完成了总RNA测序。