Impact of low dose glucocorticoids on clinical outcomes in patients undergoing surgical procedures for abdominal sepsis: a multicenter retrospective cohort study

The clinical dataset for this study was derived from two prominent healthcare institutions: the Chinese People's Liberation Army (PLA) General Hospital, which boasts 4,000 patient beds, and the PLA Air Force Medical Center, equipped with 1,500 patient beds. This retrospective cohort study included a 1:1 propensity score–matched cohort of surgical patients afflicted with abdominal sepsis from January, 2008, through December, 2022. Patients were classified into low-GCs, high-GCs, and non-GCs groups according to the dosage of steroids used intraoperatively, and in-hospital mortality was designated as the primary outcome.

本研究所使用的临床数据集源自两家知名医疗机构：拥有4000张床位的中国人民解放军（PLA）总医院，以及拥有1500张床位的中国人民解放军空军军医中心。本研究为回顾性队列研究，纳入2008年1月至2022年12月期间罹患腹部脓毒症的手术患者，按1:1比例进行倾向得分匹配。研究人员根据患者术中使用的糖皮质激素剂量，将其分为低剂量糖皮质激素组（low-GCs）、高剂量糖皮质激素组（high-GCs）及非糖皮质激素组（non-GCs），并以院内死亡率作为主要研究结局。