Expression data from human 3D skin models treated with synthetic pseudo-ceramide for medical containing steroid cream

Ceramides in the stratum corneum (SC) play an important role in the epidermal barrier function. We focused on these functions and developed a synthetic pseudo-ceramide for medical (SPCM)-containing steroid cream [SPCM (+)]. This cream forms films on the skin surface with multilamellar structures, like the human SC, and exerts anti-inflammatory effects through steroids. However, the preventive effects of this cream on disruption of skin barrier remain unclear. This study aimed to analyze the efficacy of SPCM (+) using human three-dimensional (3D) skin models. In this data set, we included expression data from human 3D skin models treated with or without SPCM (+) under exposure to V8 protease derived from Staphylococcus aureus.

角质层（stratum corneum, SC）中的神经酰胺在表皮屏障功能中发挥关键作用。本研究围绕此类功能展开，开发了一款添加合成医用假神经酰胺（synthetic pseudo-ceramide for medical, SPCM）的类固醇乳膏[SPCM (+)]。该乳膏可在皮肤表面形成与人类角质层结构相似的多层膜状结构，并通过类固醇成分发挥抗炎作用。然而，该乳膏对皮肤屏障破坏的预防作用仍有待阐明。本研究旨在借助人类三维（3D）皮肤模型，分析SPCM (+)的应用功效。本数据集包含经金黄色葡萄球菌（Staphylococcus aureus）来源的V8蛋白酶处理的人类3D皮肤模型的表达数据，这些模型分为施加SPCM (+)组与未施加SPCM (+)组。