METTL14-mediated N6-methyladenosine modification of Col17a1/Itgα6/Itgβ4 governs epidermal homeostasis [RNA-Seq]

To elucidate the role of METTL14-mediated m6A modification in epidermal development, we conditionally knocked out the m6A methyltransferase METTL14 in mouse epidermal keratinocytes. We then performed RNA-seq analysis of epidermal keratinosis from P0 control mice (K14Cre,Mettl14F/+) and cKO mice (K14CreMettl14F/F). We performed RNA-seq analysis of epidermal keratinosis from P0 control mice (K14Cre,Mettl14F/+) and cKO mice (K14CreMettl14F/F).

为阐明METTL14介导的N6-甲基腺嘌呤（m6A）修饰在表皮发育中的作用，我们在小鼠表皮角质形成细胞中条件性敲除了m6A甲基转移酶METTL14。随后，我们对出生后第0天（P0）对照组小鼠（K14Cre,Mettl14F/+）与条件性敲除（cKO）小鼠（K14CreMettl14F/F）的表皮角化组织进行了RNA测序（RNA-seq）分析。我们对出生后第0天（P0）对照组小鼠（K14Cre,Mettl14F/+）与条件性敲除（cKO）小鼠（K14CreMettl14F/F）的表皮角化组织进行了RNA测序（RNA-seq）分析。