Supplementary Material for: Merkel Cell Carcinoma Involving the Cerebrospinal Fluid: A Case Report

Merkel cell carcinoma (MCC) is a rare skin cancer with very low incidence and so community oncologists do not encounter many cases of this pathology in their day-to-day practice. Central nervous system (CNS) involvement by Merkel cell carcinoma is an extremely rare manifestation of this already rare pathology, and so not many cases are available in the literature. There are no specific guidelines for treatment of MCC involving the CNS, and so description of every single case of MCC involving CNS, is of utmost importance so as a) to help increase awareness of this entity among clinicians, b) help highlight different treatment approaches being implemented at different facilities, and c) eventually help develop best treatment guidelines to treat such cases. We present a case of an 83-year-old woman that was seen at our facility with MCC involving the cerebrospinal fluid (CSF).

默克尔细胞癌（Merkel cell carcinoma, MCC）是一种发病率极低的罕见皮肤恶性肿瘤，社区肿瘤科医师在日常临床实践中极少接触此类病例。中枢神经系统（central nervous system, CNS）受累是本已罕见的默克尔细胞癌极为罕见的临床表现，相关文献报道的病例数量寥寥。目前尚无针对中枢神经系统受累型默克尔细胞癌的特异性治疗指南，因此对每一例中枢神经系统受累的默克尔细胞癌病例进行详实报道均具有至关重要的意义：一是可帮助临床医师提升对该疾病的认知；二是能够助力梳理不同医疗机构所采用的多样化治疗方案；三是最终可为制定此类病例的最优治疗指南提供实践依据。本文报告1例于我院就诊的83岁女性患者，该患者确诊为脑脊液（cerebrospinal fluid, CSF）受累的默克尔细胞癌。